Cell-Free DNA: a clear biomarker

Donor-derived cell-free DNA: a direct indicator of transplanted organ damage

Cell-Free DNA (cfDNA) is fragmented DNA in the bloodstream that originates from cells undergoing cell injury and death.

When graft injury occurs, donor-derived cell-free DNA (dd-cfDNA) increases in the blood.

AlloSeq cfDNA measures dd-cfDNA and can be a powerful, non-invasive tool assisting in organ transplant surveillance.

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dd-cfDNA has been shown to be more accurate than serum creatinine in diagnosis of active rejection.

 

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References:

1 Grskovic M, Hiller DJ, Eubank LA, et al. Validation of a clinical-grade assay to measure donor-derived cell-free DNA in solid organ transplant recipients. J Mol Diagn. 2016;18:890.
2 Bloom RD., Bromberg JS, Poggio E, et al. Cell-free DNA and active rejection in kidney allografts. J Am SocNephrol. 2017; 28:2221.
3 Bromberg JS, Brennan DC, Poggio E, et al. Biological variation of donor-derived cell-free DNA in renal transplant recipients: clinical implications. J Appl Lab Med. 2017; 2:309.