HLA Disease associations

Olerup SSP kits for the screening of HLA-alleles associated with diseases.

There are autoimmune conditions with a strong association with HLAs, such as: Ankylosing Spondylitis associated to HLA-B*27; Narcolepsy a neurological disease closely associated with the HLA-DQB1*06:02 and over 95% of patients with Coeliac Disease have some isoform of HLA-DQ2 or DQ8.

Drug hypersensitivity: Abacavir is a nucleoside reverse transcriptase inhibitor used in conjunction with other antiretroviral agents in the treatment of HIV infection. Hypersensitivity to abacavir is immunologically mediated, driven by conventional MHC-I antigen presentation and activation of HLA-B*57:01.

All kits are available including Master Mix without Taq Polymerase. The Master Mix contains cresol red, glycerin, PCR buffer and dNTPs.